Dental Amalgams InformationANILINE-INDUCED TOXICITIES FROM LOCAL ANESTHETICSAniline compounds are well-documented human poisons 5: classic human carcinogens 21,31 and neurotoxins. The most effective route of delivery is injection into the human blood stream 6. Symptoms of anilism poisoning develop at ingestion levels greater than I gram, manifesting as methemoglobanemia, headache, paresthesia, hyperalgesia, polyneuritis, cardiac arrhythmias, dizziness, hypotension, convulsion, muscle weakness, and/or digestive derangement. German literature32 states that the hydroxyaniline form induces allergies in humans in addition to other known neurotoxicities. Experimental neurotoxicity of these nitrobenzene compounds (C6H5NO2) includes animal evaluation of nystagmus, opisthotonus, loss of righting reflex, tremors, paralysis, and coma. Cerebellar Purkinje cell degeneration in animals is observed in addition to focal malacia with reactive gliosis or vacuolization in cerebellar peduncles and medulla oblongata. Of serious concern in its implications for human beings is the ability of the aniline derivative of lidocaine, 2,6-dimethylaniline, to easily cross over to brain tissue and alter gross neurocellular structures in animals33. A Brief History of Aniline Homolog Cancer Induction The study of chemical carcinogenesis begins in 1775 when Dr. Percivall Pott, a surgeon at St. Bartholomew's Hospital in England, ascribed cancer scroti to contamination of the skin by chimney soot. One hundred years later in 1875, Von Volkmann observed occupational skin tumors among workers in the tar and paraffin industry at Halle. In 1876 Joseph Bell of Edinburgh described the "paraffin cancer" of Scotland. The coal tar dye industry founded by William Henry Perkins in 1856 was quickly controlled by the Germans who owned 80% of the market up to World War I. Bladder cancer among aniline dye workers was first described by Dr. Ludwig Rehen of Germany in 1895. In 1915 Yamagiwa and Ichikawa deliberately produced malignant epithelial tumors by application of coal tar to the ears of rabbits. In 1922 Passey produced malignant growths by painting the skins of mice with coal tar ethereal extracts. In 1938, Hueper, Wiley, and Wolfe first reported successful induction of bladder cancer in dogs by repeated injections of 2-napthylamine. Smaller doses and relatively short exposures to 2-napthylamine are very hazardous in man 5,7. Tumors induced by coal tar dyes develop from 3 to 36 years after exposure 5,6. It is worthy of note that it was in 1905, that Einhorn developed the local anesthetic, novacaine, from the aniline homolog, hydroxyaniline. |
ART |AWARDS
| BODY |
BOOKS | CALENDAR | CONTACT
US | ENNEAGRAM | FREE
STUFF | GUEST BOOK | HOLISTIC
PSYCHOLOGY | HOME
FURNISHINGS | HUMAN RIGHTS | LINKS
| MARKETING | MEDICAL
FREEDOM | MILLENNIUM | MIND
| NEWSLETTERS | ORDER
| PRACTITIONERS | PRODUCTS
| RESOURCES | SCHOOLS
| SITE SEARCH ENGINE | SERVICES
| SITE MAP | SOUL
| SUBSCRIBE
TO FREE NEWSLETTER | HOME
| E-mail us:
heall@heall.com or call , M-F, 9-5 MST
Disclaimer: Information is
provided for educational purposes only. It is not intended as diagnosis or
recommendation for treatment of disease. Please consult your physician for
medical advice. No claim is made to the therapeutic benefits of any product
or service listed on the HEALL web site. Copyright 1997, 1998, 1999, 2000.
All rights reserved